For the treatment and prevention of fleas and ticks on dogs and puppies from 8 weeks of age. Frontline Plus combines fipronil, the active ingredient in all other Frontline products, with (S)-methoprene, an insect growth regulator. This combination effectively kills fleas on the pet, and breaks the flea life cycle by inhibiting the development of flea eggs and larvae. Frontline Plus protects your pet against most disease-causing ticks as well. With regular Frontline Plus treatments, your pet is set to be flea free, tick free and carefree! When you use Frontline Plus, the active ingredients are rapidly distributed through your dog's coat. In addition, Frontline Plus is completely waterproof. In order to obtain the best results, it is recommended that your dog neither be bathed nor shampooed for 3 days before, or for 3 days after the application, as this will decrease the duration of activity.